Colief Infant Drops (15ml / 90 servings) [Nov2024]

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Crying baby? Help ease colic symptoms with Colief!

Trusted by mums and recommended by healthcare professionals, Colief® Infant Drops is the original lactase enzyme and has been on the market for over 20 years.

Colief® Infant Drops are completely natural and break down lactose into simpler sugars, glucose and galactose, making it easier for your baby to digest their feeds and reducing their discomfort.

The drops are suitable for use from birth onwards, even in premature babies. They can be used at every feed until the baby is around three to four months old.

At this point in time, the baby’s body should be able to produce enough lactase enzyme on its own and the amount of Colief® added to milk can be gradually withdrawn.

However, if symptoms persist you can continue to use Colief® Infant Drops for as long as it is needed.

More Details

Colief® Infant Drops helps to break down the lactose in a baby's usual milk (breast milk or infant formula) before the baby is fed, making the milk more easily digestible.

• Safe from birth
• Clinically Proven
• Can be used together with breastmilk or formula milk



Glycerol, Aqueous Lactase Enzyme

Nutritional Information

Lactase Enzyme (Kluyveromyces lactis) 4,500 FCC NLU/g

Typical Nutritional Information per 100g:

Energy (EU) 128 kcal / 537 kJ
Fat 0g
Carbohydrates 54g
Of which sugars 0g
Protein 4g
Salt (Sodium) 0g

*Naturally produced product nutritional content may vary.



Infant Formula

  1. Make up the baby’s feed carefully according to the manufacturer’s instructions.
  2. Add 4 drops of Colief® to formula that is warm (not hot).
  3. Shake the feed occasionally, and feed the baby after half an hour, having checked that the bottle is at the correct feeding temperature.
  4. Discard any unused feed.

Breast Feeding

  1. Express a few tablespoons of breast milk into a small sterilised container.
  2. Add 4 drops of Colief®.
  3. Give to the baby on a sterilized, plastic spoon.
  4. Continue breastfeeding as normal.

Important Notice


Colief® Infant Drops can be added to the baby's milk each time you breast or bottle feed. Do not give the drops to your baby directly. Please read the enclosed leaflet carefully. Do not use if the seal is broken on the bottle. 


Please store below 25°C and in an upright position. Once opened refrigerate when possible and discard after 3 months. Keep out of the reach of children. Do not use after the best before date stated on pack.


  • What does Colief do?
    The addition of Colief® Infant Drops to the baby’s usual milk compensates for a possible temporary lactase deficiency in the baby’s digestive system. Colief® Infant Drops added to a baby’s usual milk greatly reduces the level of lactose by breaking it down into glucose and galactose before the baby is fed. Studies have shown that the hours of crying may be greatly reduced when a baby’s usual milk is treated with Colief®.
  • What does Colief contain?
    The only ingredients in Colief® are lactase enzyme (which should be naturally present in a normal, developed digestive system), glycerol (or “glycerine”-which is also naturally present in the body as part of the process of converting fats to energy), and water. None of these ingredients has ever been shown to pose a risk to health.
  • What is lactase enzyme?
    Milk, infant formulas, breast milk, and dairy products all contain a complex sugar (disaccharide) called lactose. Lactase is the enzyme our bodies need to produce to break down the lactose in milk and dairy products into the simple sugars (monosaccharides) glucose and galactose. These can then be absorbed as part of the normal digestive process.
  • Are the drops suitable for vegetarians?
    Yes. Glycerol is derived from vegetable sources, and the lactase enzyme is derived from yeast.
  • Can I use Colief with goat's-milk-based infant formula?
    Yes. Goat’s-milk-based infant formula contains lactose the same as any other normal formula. Use Colief® Infant Drops the same way as used with other formula.
  • Can I use Colief with soy formula or lactose-free formula?
    There’s no point using Colief® with soy or lactose-free formulas. These do not contain lactose, so Colief® will have no active effect.
  • Does Colief have any side effects?
    When babies begin taking milk treated with Colief®, there may be a change in stool pattern. The stools may then resemble those of a breastfed baby-looser and more frequent-even if formula feeding. If you are happy that the baby is otherwise well, gaining weight and urinating normally, there should be no cause for concern. If the drops seem to be working well, you might try reducing the number of drops used at each feed.

    If you have any concerns regarding your baby’s health, you should consult a health care professional as soon as possible.
  • How does Colief work for breastfeeding?
    If drops were given directly to the baby, the acid in the upper digestive tract would quickly change the nature of the enzyme and render Colief® ineffective. However, mixing 4 drops of Colief® with a little expressed foremilk* appears to protect the active ingredient, lactase enzyme. The foremilk preparation provides a lining to the baby’s upper digestive tract, mixing with the breast milk and working to reduce the lactose level of the milk.

    We believe that in this form, the enzyme has an effective “working life” of approximately 30 minutes. Laboratory trials have shown that 4 drops of Colief® in 3.38 fl oz of infant milk at body temperature will break down approximately 70% of the lactose in 30 minutes.

    * Foremilk contains a concentration of the lactose in breast milk.

  • How often can you use Colief? And for how long?
    Colief Infant Drops can be used at every feeding until the baby is 3 to 4 months old, by which time the signs of colic should have disappeared. Colief can then be withdrawn gradually from use, first by halving the drops per feed, then using at alternative feeds, then one feed per day before complete withdrawal. If at any stage the signs of colic return, revert to previous dosage.
  • I am a breastfeeding "on-demand", every hour or two. Should I still use 4 drops of Colief at every feed?

    If you are feeding this frequently, you may find it convenient to express approximately half a cup of foremilk* and store this in a refrigerator. Pour a few tablespoons, warm it to body temperature, add Colief, and give this to your baby before each feeding.

    If the feedings are small-say 50ml each-you may be able to use only 2 drops of Colief per feeding. It is worth remembering that most of the lactose is concentrated in the foremilk at the beginning of every feeding.

    * Foremilk contains a concentration of the lactose in breast milk.

  • Where has Colief been researched?
    Colief® was tested at Cork University Hospital, Ireland, by Professor Kearney in the early 1990s to demonstrate that a lactose-reduced feed was effective in reducing infant colic. His results were presented to the Royal College of Pediatricians at its annual meeting in spring 1994 and published in the Journal of Human Nutrition and Dietetics in September 1998. These results were confirmed in a larger study recently completed at Guy’s Hospital, London, by Dr Dipak Kanabar and published in the Journal of Human Nutrition and Dietetics in October 2001.

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